A double blind randomized pilot trial of naloxone in the treatment of acute ischemic stroke
- 1 December 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neurological Sciences
- Vol. 12 (6), 557-563
- https://doi.org/10.1007/bf02336951
Abstract
Attention has focused on naloxone, an opiate receptor antagonist, because of its potential benefit in reversing neurological damage after acute cerebral ischemia. To evaluate the safety and possible efficacy of high-dose naloxone in ischemic stroke patients we planned a double blind pilot study. Between January 1989 and May 1990 24 patients were randomly assigned to the naloxone or placebo group according to age and neurological deficit. Naloxone was given in a loading dose of 5 mg/kg over 10 minutes followed by a 24-hour infusion at the rate of 3.5mg/kg/h. 10 patients experienced minor side effects but none of them had to discontinue the treatment. 9 patients improved: 6 in the naloxone group and 3 in the placebo group, but no significant difference was found using the non parametric Mann-Whitney test. Our study suggests that naloxone is safe at the dose used, but the results do not support the planning of similar trials on a larger scale.Keywords
This publication has 39 references indexed in Scilit:
- Spontaneous improvement after acute ischemic stroke. A pilot study.Stroke, 1990
- Kappa-opioid receptor changes and neurophysiological alterations during cerebral ischemia in rabbits.Stroke, 1990
- High-dose intravenous naloxone for the treatment of acute ischemic stroke.Stroke, 1990
- Intravenously and iontophoretically administered naloxone reverses ischemic changes in rat hippocampus.Stroke, 1989
- A dose-escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia.Stroke, 1986
- Naloxone effect on the neurological deficit induced by forebrain ischemia in ratsLife Sciences, 1986
- CSF and plasma levels of pro-opiomelanocortin-related peptides in reversible ischaemic attacks and strokes.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Naloxone ameliorates the pathophysiologic changes which lead to and attend an acute stroke in stroke-prone/SHR.Stroke, 1984
- A double blind trial of naloxone in the treatment of acute stroke.Stroke, 1984
- Naloxone therapy during focal cerebral ischemia evaluation in a primate model.Stroke, 1984