Effect of Allergic Diseases on Keratoconus Severity
- 25 March 2016
- journal article
- research article
- Published by Taylor & Francis Ltd in Ocular Immunology and Inflammation
- Vol. 25 (3), 418-423
- https://doi.org/10.3109/09273948.2016.1145697
Abstract
Purpose: To investigate the association between keratoconus (KC) and allergic diseases. Methods: In a prospective age- and sex-matched case–-control study clinical data of 885 KC patients and 1526 controls were evaluated regarding the presence of various allergic diseases. Severity of KC and ophthalmic parameters of KC patients were compared between KC patients with and without allergic diseases. Results: The prevalence of allergic diseases was significantly higher in KC patients. KC patients with vernal keratoconjunctivitis (VKC) or allergic conjunctivitis (AC) had significantly thinner and steeper corneas in comparison with non-allergic KC patients. Only VKC and AC were significantly associated with KC severity. Conclusions: Patients with VKC or AC were at increased risk of KC. They had more severe KC and should be closely followed up and intensively treated.Keywords
This publication has 32 references indexed in Scilit:
- New Twists to an Old Story: Novel Concepts in the Pathogenesis of Allergic Eye DiseaseCurrent Eye Research, 2013
- The Role of Atopy in Corneal Graft Survival in KeratoconusCornea, 2011
- Computerized corneal tomography and associated features in a large New Zealand keratoconic populationJournal of Cataract & Refractive Surgery, 2011
- Keratoconus in Asians: demographics, clinical characteristics and visual function in a hospital‐based populationClinical & Experimental Ophthalmology, 2011
- The Association of Keratoconus With Immune DisordersCornea, 2010
- Comparative Study of Graft Rejection in Keratoconus Patients With and Without Self-Reported AtopyCornea, 2009
- Clinical Profile and Risk Factors for Keratoplasty and Development of Hydrops in North Indian Patients With KeratoconusCornea, 2009
- The genetics of keratoconusClinical & Experimental Ophthalmology, 2001
- Expression of chemokine receptors in vernal keratoconjunctivitisBritish Journal of Ophthalmology, 2001
- Evaluation of a self-administered questionnaire on atopic diseases. Discrepancy between self-reported symptoms and objective signsEuropean Journal of Public Health, 2000