Polymorphism at the porcine Dominant white/KIT locus influence coat colour and peripheral blood cell measures
- 8 June 2005
- journal article
- research article
- Published by Wiley in Animal Genetics
- Vol. 36 (4), 288-296
- https://doi.org/10.1111/j.1365-2052.2005.01320.x
Abstract
We have examined the phenotype of different KIT genotypes with regard to coat colour and several blood parameters (erythrocyte numbers and measures, total and differential leucocyte numbers, haematocrit and haemoglobin levels and serum components). The effect of two different iron supplement regimes (one or two iron injections) on the blood parameters was also examined. For a total of 184 cross-bred piglets (different combinations of Hampshire, Landrace and Yorkshire) blood parameters were measured four times during their first month of life, and the KIT genotypes of these and 70 additional cross-bred piglets were determined. Eight different KIT genotypes were identified, which confirms the large allelic diversity at the KIT locus in commercial pig populations. The results showed that pigs with different KIT genotypes differ both in coat colour and in haematological parameters. In general, homozygous Dominant white (I/I) piglets had larger erythrocytes with lower haemoglobin concentration, indicating a mild macrocytic anaemia. The effect of two compared with one iron injection was also most pronounced for the I/I piglets.Keywords
This publication has 25 references indexed in Scilit:
- Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte functionAnimal Genetics, 2005
- A Sensitive Method for Detecting Variation in Copy Numbers of Duplicated GenesGenome Research, 2003
- A large duplication associated with dominant white color in pigs originated by homologous recombination between LINE elements flanking KITMammalian Genome, 2002
- An evaluation of iron-dextran supplementation in piglets administered by injection on the first, third or fourth day after birthResearch in Veterinary Science, 1999
- MOLECULAR AND DEVELOPMENTAL GENETICS OF MOUSE COAT COLORAnnual Review of Genetics, 1994
- Molecular Basis of Human PiebaldismJournal of Investigative Dermatology, 1994
- The gene for dominant white color in the pig is closely linked to ALB and PDGFRA on chromosome 8Genomics, 1992
- Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.Genes & Development, 1989
- The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogeneCell, 1988
- The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locusNature, 1988