Retinoid Signaling Determines Germ Cell Fate in Mice
Top Cited Papers
- 28 April 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 312 (5773), 596-600
- https://doi.org/10.1126/science.1125691
Abstract
Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1-knockout mouse embryos, germ cells enter meiosis precociously, as if in a normal ovary. Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.Keywords
This publication has 27 references indexed in Scilit:
- Germ cells enter meiosis in a rostro‐caudal wave during development of the mouse ovaryMolecular Reproduction and Development, 2004
- Retinoic Acid Inhibits Rat XY Gonad Development by Blocking Mesonephric Cell Migration and Decreasing the Number of GonocytesBiology of Reproduction, 2004
- Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonadsDevelopment, 2003
- Effects of retinoids on the meiosis in the fetal rat ovary in cultureMolecular and Cellular Endocrinology, 2000
- Distinct functions forAldh1 andRaldh2 in the control of ligand production for embryonic retinoid signaling pathwaysDevelopmental Genetics, 1999
- Segregation of Retinoic Acid Effects on Fetal Ovarian Germ Cell Mitosis Versus Apoptosis by Requirement for New Macromolecular SynthesisEndocrinology, 1999
- AGN193109 Is a Highly Effective Antagonist of Retinoid Action in Human Ectocervical Epithelial CellsPublished by Elsevier BV ,1996
- Proliferation and migration of primordial germ cells in We/We mouse embryosDevelopmental Dynamics, 1993
- Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.Genes & Development, 1991
- Does the rete ovarii act as a trigger for the onset of meiosis?Nature, 1974