The impact of vitamin D deficiency on diabetes and cardiovascular risk
- 1 April 2010
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Endocrinology, Diabetes and Obesity
- Vol. 17 (2), 113-119
- https://doi.org/10.1097/med.0b013e3283372859
Abstract
To review the association between vitamin D deficiency and diabetes and cardiovascular risk. Vitamin D deficiency is newly recognized as a common condition of increasing prevalence worldwide. Clinically, vitamin D has an established role in calcium and bone metabolism and has recently been shown to be associated with increased risk of developing type 1 and type 2 diabetes mellitus and cardiovascular disease (CVD), as well as with cardiovascular risk factors such as hypertension and obesity. The molecular mechanisms of these associations remain incompletely understood. The active metabolite of vitamin D regulates transcription of multiple gene products with antiproliferative, prodifferentiative, and immunomodulatory effects. Although vitamin D deficiency is frequently unrecognized clinically, laboratory measurement is easy to perform and treatment of vitamin D deficiency is relatively well tolerated and inexpensive. Limited, yet promising, results of proof-of-concept intervention studies of using vitamin D in diabetes will be presented. The high prevalence of vitamin D deficiency and plausible molecular mechanisms linking this to diabetes and cardiovascular risk suggest treatment of vitamin D deficiency to prevent and/or treat diabetes is a promising field to explore.Keywords
This publication has 83 references indexed in Scilit:
- 1,25(OH) 2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes MellitusCirculation, 2009
- Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004JAMA Internal Medicine, 2009
- Effect of Calcium and Vitamin D Supplementation on Blood PressureHypertension, 2008
- Vitamin D Deficiency and Risk of Cardiovascular DiseaseCirculation, 2008
- Relationships of low serum vitamin D3with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesityNutrition Journal, 2008
- Vitamin D DeficiencyThe New England Journal of Medicine, 2007
- Prevalence of Cardiovascular Risk Factors and the Serum Levels of 25-Hydroxyvitamin D in the United StatesArchives of Internal Medicine, 2007
- Inflammation and insulin resistanceJCI Insight, 2006
- Global and societal implications of the diabetes epidemicNature, 2001
- Vitamin D Intoxication Associated with an Over-the-Counter SupplementThe New England Journal of Medicine, 2001