Lack of influence of intravenous contrast on head and neck IMRT dose distributions
Open Access
- 1 January 2008
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Oncologica
- Vol. 47 (1), 90-94
- https://doi.org/10.1080/02841860701418861
Abstract
Purpose. Intravenous (IV) contrast at the time of CT-Simulation facilitates radiotherapy contouring, but may introduce a discrepancy between planned and delivered dose due to density variation in blood vessels. Here, the effect of physiologic and non-physiologic extremes of IV contrast densities on intensity modulated radiotherapy (IMRT) plans for patients with head and neck cancer was investigated. Methods and materials. This planning study was conducted using IV contrast CT scans of ten patients with squamous cell cancer of the head and neck treated with IMRT. The target volumes and normal tissues, including the blood vessels of the head and neck, were contoured and IMRT plans were created according to RTOG Protocol 0022. The density within the blood vessels was then virtually altered to mimic non-contrast and extreme (bone and air) densities. The dose was then recalculated using the same IMRT plan. Plans obtained with and without density overrides were then compared. Results. The change in planning target volume (PTV) coverage for plans with and without IV contrast was minimal. The volume of the PTVs covered by the 93% and 100% isodoses changed on average by 0.57%. The minimum dose to PTVs varied by a maximum of 0.17 Gy. The maximum point dose to critical organs changed by a maximum of 0.12 Gy (brainstem). Non-physiologic extremes of density within blood vessels also resulted in minimal changes in tumor or normal tissue dosimetry. Conclusion. The use of IV contrast at time of CT-simulation does not significantly affect dose calculation in head and neck IMRT plans.Keywords
This publication has 12 references indexed in Scilit:
- Influence of intravenous contrast agent on dose calculations of intensity modulated radiation therapy plans for head and neck cancerRadiotherapy and Oncology, 2006
- Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trialInternational Journal of Radiation Oncology*Biology*Physics, 2006
- Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysisThe Lancet, 2006
- Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patientsInternational Journal of Radiation Oncology*Biology*Physics, 2006
- The Effect of Intravenous Contrast on Intensity-Modulated Radiation Therapy Dose Calculations for Head and Neck CancerAmerican Journal of Clinical Oncology, 2005
- Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategiesCMAJ : Canadian Medical Association Journal, 2005
- Contrast effects on dosimetry of a partial breast irradiation systemMedical Physics, 2004
- Influence of iodine contrast agent on the range of ion beams for radiotherapyMedical Physics, 2004
- Salivary Gland Sparing and Improved Target Irradiation by Conformal and Intensity Modulated Irradiation of Head and Neck CancerWorld Journal of Surgery, 2003
- Functional imaging of tumors using CT and iodinated contrast media of different molecular weights.Academic Radiology, 2002