Relationship Between HbA1c on Target, Risk of Silent Hypoglycemia and Glycemic Variability in Patients with Type 2 Diabetes Mellitus

Abstract

Objective: We aimed to compare time spent at low glucose level (silent hypoglycemia, glucose Research Design and Methods: In 108 type 2 diabetic patients the interstitial glucose concentration was measured with CGMS (Continuous Glucose Monitoring System) over 72 h. Patients were divided in group 1 with an HbA1c Results: 24% in group 1 experienced silent hypoglycemia vs. 11% in group 2 (n. s.), duration of silent hypoglycemia over 48 h was 27±71 min vs. 7±36 min (n. s.). This was also valid for the subgroups treated with insulin. Patients in group 2 had a significantly higher standard deviation of average glucose (2.3±0.8 vs. 1.3±0.6; pConclusion: Silent hypoglycemia tended to occur more often and to last longer in patients with HbA1c 7% had a higher glycemic variability. HbA1c >7% wasn’t a reliable indicator of lower risk of hypoglycemia.