The significance of CO2 combining power in predicting prognosis of patients with stage II and III colorectal cancer

Abstract

Aim: This study was to evaluate whether CO₂CP level in venous blood could predict prognosis of patients with colorectal cancer (CRC). Materials & methods: A retrospective cohort of 238 patients with CRC who received surgical resection and 176 CRC Stage IV patients were included. A total of 114 healthy people were recruited as control. CO₂CP levels were obtained from medical records. Survival analysis was performed to evaluate CO₂CP predictive potential. The patients were divided into CO₂CP high or low group based on CO₂CP optimal cut-off values. Conclusion: The decreased CO₂CP in CRC patients was associated with advanced clinical stage, and suggested that decreased CO₂CP may predict the worse outcomes of disease-free survival in II/III stage CRC patients.