Synthesis and In Vitro Antioxidant Activity of some New Fused Pyridine Analogs

Abstract

A new series of pyrano[3,2‐c]pyridines, pyrazolo[4,3‐c]pyridines, and pyrido[4,3‐d]pyrimidines were synthesized and screened for their in vitro antioxidant activity. Compounds 13, 14, 15, 23, 29, 30, and 31 exhibited the most active oxygen free‐radical scavenger activity with percentage inhibitions of 99.4, 99.6, 99.8, 97.3, 99.0, 99.3, and 99.5 %; respectively, which is comparable to the curcumin potency. Most of the tested compounds proved to be safe towards peripheral multinuclear neutrophils (PMNs). The detailed synthesis and antioxidant activity data are reported.