Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression
Open Access
- 1 August 2000
- journal article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 275 (32), 24500-24505
- https://doi.org/10.1074/jbc.m003145200
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- Prostate Cancer Cell Cycle Regulators: Response to Androgen Withdrawal and Development of Androgen IndependenceJNCI Journal of the National Cancer Institute, 1999
- THE BIOLOGY OF HORMONE REFRACTORY PROSTATE CANCERUrologic Clinics of North America, 1999
- New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayProceedings of the National Academy of Sciences of the United States of America, 1999
- The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayProceedings of the National Academy of Sciences of the United States of America, 1998
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- Prostate Stem Cell CompartmentsThe American Journal of Pathology, 1998
- Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionProceedings of the National Academy of Sciences of the United States of America, 1998
- Role of p27 in prostate carcinogenesis.Cancer and Metastasis Reviews, 1998
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancerThe Prostate, 1996