Mucociliary Clearance and Buffered Hypertonic Saline Solution
- 1 April 1997
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 107 (4), 500-503
- https://doi.org/10.1097/00005537-199704000-00013
Abstract
Nasal irrigations have been used for centuries without any scientific data to determine efficacy. For 10 years, the senior author has used buffered hypertonic saline nasal irrigation for patients with acute/chronic sinusitis and for those having undergone sinus surgery. A simple study was undertaken using volunteers without any significant sinonasal disease. Patients served as their own control using a saccharin clearance test before any nasal irrigation was used. Patients then used one of two solutions to irrigate their nose‐buffered normal saline or buffered hypertonic saline‐and were then retested. On a separate day, the control test was repeated, followed by irrigation with the alternate solution and a second saccharin clearance test. The outcome showed buffered hypertonic saline nasal irrigation to improve mucociliary transit times of saccharin, while buffered normal saline had no such effect.Keywords
This publication has 9 references indexed in Scilit:
- Chronic Sinusitis: A Medical or Surgical Disease?Otolaryngologic Clinics of North America, 1996
- Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects.Thorax, 1993
- The relationship between the nasal cycle and mucociliary clearanceThe Laryngoscope, 1992
- Efficacy of a saccharin test for screening to detect abnormal mucociliary clearanceRespiratory Medicine, 1984
- Mucociliary clearance in chronic sinusitis: Related human nasal clearance and in vitro bullfrog palate clearance1Biorheology, 1983
- Effect of pH, Viscosity and Ionic-Strength Changes on Ciliary Beating Frequency of Human Bronchial ExplantsClinical Science, 1983
- pH Effects on Ciliomotility and Morphology of Respiratory MucosaArchives of environmental health, 1977
- Über das physikalisch-chemische Verhalten des NasenschleimsEuropean Archives of Oto-Rhino-Laryngology, 1964
- REDUCTION OF SPUTUM VISCOSITY BY A WATER AEROSOL IN CHRONIC BRONCHITISThe Lancet, 1960