Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies.
Open Access
- 1 July 1979
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 150 (1), 108-116
- https://doi.org/10.1084/jem.150.1.108
Abstract
Two new lymphocyte antigens, provisionally designated Qat-4 and Qat-5 have been identified with two different hybridoma-derived, monoclonal AKR antiC57BL/6 antibodies. These antigens are governed by genes located to the right (distal) end of the H-2 complex, within the Qa-2,3 region. Qat-4 and Qat-5 antigens which do not seem to be identical with Qa-2,3 or TL antigens are absent from Ig/ lymphocytes and thymocytes. They are only present on a fraction of peripheral T cells. Thus, Qat-4 is expressed on 70%, and Qat-5 on 30% of splenic and lymph node T cells, Qat-4 is also found on the majority of Ig- cells from athymic nude mice. These findings illustrate the complexity of the chromosome segment between the H-2D and Tla loci and they emphasize the role of major histocompatibility complex-associated genes for the differentiation of T cells into different subpopulations with possibly distinct immunologic functions.Keywords
This publication has 6 references indexed in Scilit:
- Monoclonal Antibodies against Murine Cell Surface Antigens: Anti-H-2, Anti-Ia and Anti-T Cell AntibodiesCurrent Topics in Microbiology and Immunology, 1979
- "Panning" for lymphocytes: a method for cell selection.Proceedings of the National Academy of Sciences of the United States of America, 1978
- Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouseNature, 1978
- Continuous cultures of fused cells secreting antibody of predefined specificityNature, 1975
- High frequency of T lineage lymphocytes in nude mouse spleenNature, 1974
- Growth of Primary Plasmacytomas in the Mineral Oil-Conditioned Peritoneal Environment2JNCI Journal of the National Cancer Institute, 1972