Women's Sexual Function Improves When Partners are Administered Vardenafil for Erectile Dysfunction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
- 1 November 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Sexual Medicine
- Vol. 2 (6), 819-832
- https://doi.org/10.1111/j.1743-6109.2005.00147.x
Abstract
There are limited data concerning the sexual function of women whose male partners receive pharmacological treatment for erectile dysfunction (ED). One objective of this research was to prospectively compare the efficacy of vardenafil vs. placebo administered to men with ED in improving men's and women partners’ sexual function and satisfaction. Another goal was to assess the relationship of erectile function changes in men with ED receiving treatment with sexual function changes in women partners not directly receiving treatment. A randomized, double‐blind, placebo‐controlled, multi‐institutional comparison of vardenafil vs. placebo was performed in 229 couples (treated man with ED >6 months and untreated woman partner). Co‐primary outcomes for which this research was statistically powered were Sexual Encounter Profile (SEP3) (treated man with ED) and Sexual Life Quality Questionnaire (mSLQQ‐QOL) (untreated woman partner). Erectile function changes in men with ED receiving vardenafil vs. placebo were compared at last observation carried forward (LOCF) in SEP3, International Index of Erectile Function (IIEF‐EF) and Erection Quality Scale (EQS). Sexual function at LOCF in women partners was determined by mSLQQ‐QOL and Female Sexual Function Index (FSFI). Compared with placebo at LOCF, vardenafil significantly increased least square (LS) mean scores in: (i) overall per‐treated male SEP3 success rate, IIEF‐EF, and EQS; and (ii) mSLQQ‐QOL, total FSFI and sexual desire, subjective arousal, lubrication, orgasm and satisfaction FSFI domains in untreated women partners. Treatment‐related improvement in erectile function as assessed by IIEF‐EF and EQS was correlated reliably with improvement in women partners’ FSFI total and individual domain scores. Vardenafil is an effective ED treatment in men that also significantly improves sexual function/satisfaction in untreated women partners. Women partners’ sexual function improvements relate significantly and consistently to treatment‐related improvements in men's erectile function. ED management should emphasize both members of the couple. Goldstein I, Fisher WA, Sand M, Rosen RC, Mollen M, Brock G, Karlin G, Pommerville P, Bangerter K, Bandel T‐J, and Derogatis LR for the Vardenafil Study Group. Women's sexual function improves when partners are administered vardenafil for erectile dysfunction: a prospective, randomized, double‐blind, placebo‐controlled trial. J Sex Med 2005;2:819–832.Keywords
Funding Information
- Bayer Corporation
This publication has 47 references indexed in Scilit:
- Improving the Sexual Quality of Life of Couples Affected by Erectile Dysfunction: A Double–Blind, Randomized, Placebo–Controlled Trial of VardenafilThe Journal of Sexual Medicine, 2005
- The Impact of Aging on Sexual Function and Sexual Dysfunction in Women: A Review of Population-Based StudiesThe Journal of Sexual Medicine, 2005
- Women's Sexual Pain and its ManagementThe Journal of Sexual Medicine, 2005
- Sexual Dysfunction in Women With the Metabolic SyndromeDiabetes Care, 2005
- Mode of delivery and pelvic floor muscle strength and sexual function after childbirthInternational Journal of Gynecology & Obstetrics, 2005
- Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy womenHormones and Behavior, 2004
- The female partner's satisfaction with sildenafil citrate treatment of erectile dysfunctionInternational Journal of Urology, 2004
- Endocrine Aspects of Female Sexual DysfunctionThe Journal of Sexual Medicine, 2004
- Clinical Evaluation and Management Strategy for Sexual Dysfunction in Men and WomenThe Journal of Sexual Medicine, 2004
- The Investment Model Scale: Measuring commitment level, satisfaction level, quality of alternatives, and investment sizePersonal Relationships, 1998