Terahertz pulsed imaging of freshly excised human colonic tissues
Open Access
- 27 June 2011
- journal article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 56 (14), 4333-4353
- https://doi.org/10.1088/0031-9155/56/14/008
Abstract
We present the results from a feasibility study which measures properties in the terahertz frequency range of excised cancerous, dysplastic and healthy colonic tissues from 30 patients. We compare their absorption and refractive index spectra to identify trends which may enable different tissue types to be distinguished. In addition, we present statistical models based on variations between up to 17 parameters calculated from the reflected time and frequency domain signals of all the measured tissues. These models produce a sensitivity of 82% and a specificity of 77% in distinguishing between healthy and all diseased tissues and a sensitivity of 89% and a specificity of 71% in distinguishing between dysplastic and healthy tissues. The contrast between the tissue types was supported by histological staining studies which showed an increased vascularity in regions of increased terahertz absorption.Keywords
This publication has 28 references indexed in Scilit:
- PDGF and Vessel MaturationPublished by Springer Science and Business Media LLC ,2009
- Terahertz pulsed spectroscopy of freshly excised human breast cancerOptics Express, 2009
- Tissue characterization using terahertz pulsed imaging in reflection geometryPhysics in Medicine & Biology, 2008
- A new data processing approach to reduce variations in terahertz pulsed imagingPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2008
- Terahertz Pulsed Imaging of Human Breast TumorsRadiology, 2006
- Emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasisNature Reviews Cancer, 2005
- A Multiple Scale Model for Tumor GrowthMultiscale Modeling & Simulation, 2005
- Multispectral classification techniques for terahertz pulsed imaging: an example in histopathologyMedical Engineering & Physics, 2004
- Effects of THz Exposure on Human Primary Keratinocyte Differentiation and ViabilityJournal of Biological Physics, 2003
- Visualization and classification in biomedical terahertz pulsed imagingPhysics in Medicine & Biology, 2002