Evaluation of the Effects of Laparotomy and Laparoscopy on the Immune System in Intra-Abdominal Sepsis—A Review
- 1 January 2008
- journal article
- research article
- Published by Informa UK Limited in Journal of Investigative Surgery
- Vol. 21 (6), 330-339
- https://doi.org/10.1080/08941930802438914
Abstract
This review portrays the most common experimental models of intra-abdominal sepsis. Additionally, it outlines the facts that distinguish laparotomy from laparoscopy, in respect to the immune response, when comparing these two techniques in experimental models of intra-abdominal sepsis. It describes the consequences of pneumoperitoneum and trauma produced by laparoscopy or laparotomy, respectively, on bacterial translocation and immunity. Furthermore, we report the few efforts that have been made in clinical settings, where surgeons have attempted to utilize laparoscopy as a therapeutic module when treating peritonitis or sepsis of abdominal origin. Certainly there is a need for more research in order to fortify the role of pneumoperitoneum in sepsis of abdominal origin. It seems that minimally invasive surgery will inevitably gain acceptance by surgeons, as evidence points that by inflicting less trauma the healing response is expected to be more efficient, especially in septic patients.Keywords
This publication has 66 references indexed in Scilit:
- Bacteroides: the Good, the Bad, and the Nitty-GrittyClinical Microbiology Reviews, 2007
- Effect of a pneumoperitoneum on systemic cytokine levels, bacterial translocation, and organ complications in a rat model of severe acute pancreatitis with infected necrosisSurgical Endoscopy, 2006
- Perméabilité intestinale et cirrhoseGastroentérologie Clinique et Biologique, 2006
- Early laparoscopy as a routine procedure in the management of acute abdominal pain: a review of 1,320 patientsSurgical Endoscopy, 2005
- Mini-laparotomy and full laparotomy, but not laparoscopy, alter hepatic macrophage populations in a rat modelSurgical Endoscopy, 2005
- Immunologic postoperative competence after laparoscopy versus laparotomySurgical Endoscopy, 2003
- Peritoneal, systemic, and distant organ inflammatory responses are reduced by a laparoscopic approach and carbon dioxide vs airSurgical Endoscopy, 2002
- Diagnosis and Treatment of Intra-Abdominal AbscessesSurgical Infections, 2000
- Laparoscopic repair of perforated duodenal ulcerSurgical Endoscopy, 1997
- Influence of laparoscopic and conventional cholecystectomy upon cell-mediated immunityBritish Journal of Surgery, 1995