Complex systems biology
Open Access
- 20 September 2017
- journal article
- review article
- Published by The Royal Society in Journal of The Royal Society Interface
- Vol. 14 (134), 20170391
- https://doi.org/10.1098/rsif.2017.0391
Abstract
Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades. However, not much appreciation has been granted to the realization that the human cell is an exemplary complex system. Here, I outline general design principles identified in many complex systems, and then describe the human cell as a prototypical complex system. Considering concepts of complex systems theory in systems biology can illuminate our overall understanding of normal cell physiology and the alterations that lead to human disease.Keywords
Funding Information
- National Institute of Diabetes and Digestive and Kidney Diseases (U54HL127624)
- National Cancer Institute (U54CA189201)
- National Institute of General Medical Sciences (R01GM098316)
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