Acute Immunologic Pulmonary Alveolitis
Open Access
- 1 August 1974
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 54 (2), 349-357
- https://doi.org/10.1172/jci107770
Abstract
Acute immunologic injury of rat lung has been induced by the intrabronchial injection of heterologous antibody and the intravenous injection of radiolabeled antigen. Within 4 h an acute hemorrhagic neutrophil-rich exudate develops in alveolar and interstitial areas and then gradually fades. Lung injury in this model can be quantitated by measurements of increased vascular permeability and extractable hemoglobin. By the use of immunofluorescent techniques, alveolar and interstitial deposits of antigen and antibody have been demonstrated, but not the third component of complement (C3). Although not found in relation to immune complexes, C3 is nevertheless present in damaged lung as measured by accumulation of radiolabeled C3 from the circulation. Ablation experiments indicate the requirement for both circulating neutrophils and C3 for the development of lung injury. These studies provide definition for the development of lung damage induced by immune complexes.Keywords
This publication has 17 references indexed in Scilit:
- Changes in guinea-pig lungs following the inhalation of powdered egg albumenPathology, 1972
- Acute experimental hypersensitivity pneumonitis in rabbits.Published by Elsevier BV ,1971
- THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATSThe Journal of Experimental Medicine, 1971
- Experimental Hemorrhagic Pneumonitis Produced by Heterologous Anti-Lung AntibodyThe Journal of Immunology, 1970
- Two Anticomplementary Factors in Cobra Venom: Hemolysis of Guinea Pig Erythrocytes by One of ThemThe Journal of Immunology, 1969
- C3 LEUKOTACTIC FACTORS PRODUCED BY A TISSUE PROTEASEThe Journal of Experimental Medicine, 1969
- Hypersensitivity diseases of the lungs due to fungi and organic dusts.1969
- A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITISThe Journal of Experimental Medicine, 1965
- High specific activity iodination of gamma-globulin with iodine-131 monochloride.1960
- THE ROLE OF POLYMORPHONUCLEAR LEUKOCYTES IN THE INITIATION AND CESSATION OF THE ARTHUS VASCULITISThe Journal of Experimental Medicine, 1959