Acute Hemodynamic Responses to Supplemental Oxygen and Their Prognostic Implications in Pulmonary Hypertension
Open Access
- 4 October 2012
- journal article
- Published by S. Karger AG in Respiration
- Vol. 85 (5), 400-407
- https://doi.org/10.1159/000340009
Abstract
Background: Pulmonary hypertension (PH) of various causes leads to a poor prognosis. Pulmonary vasoreactivity testing during right heart catheterization (RHC) has prognostic and therapeutic consequences. Objective: To characterize the acute hemodynamic response to short-term oxygen supplementation (SHOT) in adult PH patients and its impact on prognosis. Methods: After a stable baseline period, 104 patients with PH [pulmonary arterial hypertension (PAH; n = 56), chronic thromboembolic (PH; n = 22) or respiratory diseases (PH; n = 26)], who were mainly therapy-naïve (86.5%) (mean pO2 64.5 ± 1.2 mm Hg), received a standardized SHOT during RHC and hemodynamic response was assessed for its prognostic potential. Results: SHOT significantly reduced heart rate (HR: 78.9 ± 1.5 to 74 ± 1.5 beats/min), cardiac output (4 ± 0.1 to 3.8 ± 0.1 l/min), pulmonary arterial pressure (46.4 ± 1.3 to 42.3 ± 1.3 mm Hg) and pulmonary vascular resistance (10.1 ± 0.5 to 9.6 ± 0.5 Wood units; all p < 0.001) compared to baseline. The magnitude of this effect varied between the different PH groups. During a median follow-up of 25.1 months (range: 0.2-73.3 months), HR <72 beats/min in response to SHOT was associated with a better prognosis in patients with PH due to chronic thromboembolism to the lung and PH from chronic lung disease. Conclusions: SHOT leads to characteristic hemodynamic responses across different forms of PH. The preserved capability to acutely respond to SHOT with HR reduction is of prognostic significance in patients with non PAH PH.Keywords
This publication has 30 references indexed in Scilit:
- Assessment of pulmonary hypertension in the pediatric catheterization laboratory: Current insights from the magic registryCatheterization and Cardiovascular Interventions, 2010
- Pulmonale Hypertonie: invasive DiagnostikDeutsche Medizinische Wochenschrift (1946), 2010
- Relation of Resting Heart Rate to Prognosis in Patients With Idiopathic Pulmonary Arterial HypertensionThe American Journal of Cardiology, 2009
- Iloprost for pulmonary vasodilator testing in idiopathic pulmonary arterial hypertensionEuropean Respiratory Journal, 2009
- Hypoxia- and non-hypoxia-related pulmonary hypertension — Established and new therapiesCardiovascular Research, 2006
- Impaired Stroke Volume Response to Exercise in Pulmonary Arterial HypertensionJournal of the American College of Cardiology, 2006
- Deleterious Effects of β-Blockers on Exercise Capacity and Hemodynamics in Patients With Portopulmonary HypertensionGastroenterology, 2006
- Heart rate responses during the 6-minute walk test in pulmonary arterial hypertensionEuropean Respiratory Journal, 2006
- Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial HypertensionCirculation, 2005
- Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levelsJournal of the American College of Cardiology, 1995