Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficit hyperactivity disorder
Open Access
- 29 December 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Italian Journal of Pediatrics
- Vol. 37 (1), 60-7
- https://doi.org/10.1186/1824-7288-37-60
Abstract
Background: Attention deficit hyperactivity disorder is a behavioral syndrome of childhood characterized by inattention, hyperactivity and impulsivity. There were many etiological theories showed dysfunction of some brain areas that are implicated in inhibition of responses and functions of the brain. Minerals like zinc, ferritin, magnesium and copper may play a role in the pathogenesis and therefore the treatment of this disorder. Objective: This study aimed to measure levels of zinc, ferritin, magnesium and copper in children with attention deficit hyperactivity disorder and comparing them to normal. Methods: This study included 58 children aged 5-15 years with attention deficit hyperactivity disorder attending Minia University Hospital from June 2008 to January 2010. They were classified into three sub-groups: sub-group I included 32 children with in-attentive type, sub-group II included 10 children with hyperactive type and sub-group III included 16 children with combined type according to the DSM-IV criteria of American Psychiatric Association, 2000. The control group included 25 apparently normal healthy children. Results: Zinc, ferritin and magnesium levels were significantly lower in children with attention deficit hyperactivity disorder than controls (p value 0.04, 0.03 and 0.02 respectively), while copper levels were not significantly different (p value 0.9). Children with inattentive type had significant lower levels of zinc and ferritin than controls (p value 0.001 and 0.01 respectively) with no significant difference between them as regards magnesium and copper levels (p value 0.4 and 0.6 respectively). Children with hyperactive type had significant lower levels of zinc, ferritin and magnesium than controls (p value 0.01, 0.02 and 0.02 respectively) with no significant difference between them as regards copper levels (p value 0.9). Children with combined type had significant lower levels of zinc and magnesium than controls (p value 0.001 and 0.004 respectively) with no significant difference between them as regards ferritin and copper levels (p value 0.7 and 0.6 respectively). Conclusions: Children with attention deficit hyperactivity disorder had lower levels of zinc, ferritin and magnesium than healthy children but had normal copper levels.Keywords
This publication has 40 references indexed in Scilit:
- Effects of Zinc and Ferritin Levels on Parent and Teacher Reported Symptom Scores in Attention Deficit Hyperactivity DisorderChild Psychiatry and Human Development, 2010
- Evaluating Dopamine Reward Pathway in ADHDJAMA, 2009
- Iron deficiency and child and maternal healthThe American Journal of Clinical Nutrition, 2009
- Role of zinc in maternal and child mental healthThe American Journal of Clinical Nutrition, 2009
- The dopamine receptor D4 7‐repeat allele and prenatal smoking in ADHD‐affected children and their unaffected siblings: no gene–environment interactionJournal of Child Psychology and Psychiatry, 2008
- Combined Type Versus ADHD Predominantly Hyperactive-Impulsive Type: Is There a Difference in Functional Impairment?Journal of Developmental & Behavioral Pediatrics, 2008
- Estimated Prevalence of Attention-Deficit/ Hyperactivity Disorder Symptoms Among College FreshmenJournal of Learning Disabilities, 2008
- Effects of Iron Supplementation on Attention Deficit Hyperactivity Disorder in ChildrenPediatric Neurology, 2008
- Is iron deficiency an underlying cause of pediatric restless legs syndrome and of attention-deficit/hyperactivity disorder?Sleep Medicine, 2007
- Dopaminergic System Genes in ADHD Toward a Biological HypothesisNeuropsychopharmacology, 2002