IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN
Open Access
- 1 February 1972
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 135 (2), 298-311
- https://doi.org/10.1084/jem.135.2.298
Abstract
High and low zone antibody tolerance to bacterial flagellin can be induced in adult strain W Wistar rats by multiple injections of a cyanogen bromide (CNBr) digest of flagellin at two widely spaced dose levels. Intermediate doses of the CNBr digest produce enhanced antibody titers to flagellin rather than antibody tolerance. Studies reported in this paper revealed that both high and low zone antibody tolerance to flagellin were accompanied by heightened levels of delayed-type hypersensitivity. Conversely, when enhancement of the antibody response occurred, suppression of delayed hypersensitivity was observed.This publication has 25 references indexed in Scilit:
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