Effects of skin temperature on lesion size in fractional photothermolysis
- 24 January 2007
- journal article
- Published by Wiley in Lasers in Surgery and Medicine
- Vol. 39 (1), 14-18
- https://doi.org/10.1002/lsm.20453
Abstract
Background and Objectives Fractional photothermolysis is a new concept in cutaneous re‐modeling whereby laser‐induced microscopic zones of thermal injury (MTZ—Microscopic Treatment Zones) are surrounded by normal, viable tissue. This unique thermal damage pattern allows re‐epithelialization in less than 24 hours. To increase patient comfort level during the procedure of fractional photothermolysis, simultaneous skin cooling has been proposed and is now extensively used. The purpose of this in vitro study was to examine the influence of skin temperature on the diameter of the epidermal microthermal zone and the extent of thermal injury per unit area. The determination of the changes in these parameters that are due to skin temperature will allow the better control and understanding of fractional photothermolysis at different skin temperatures. Materials and Methods Fractional photothermolysis was performed with a 1,550 nm fiber laser (Fraxel SR® Laser) with 10 mJ per pulse on full‐thickness cadaver skin. The skin samples were brought prior to exposure to temperatures that ranged from 0 to 45°C. The epidermis of the skin samples was separated by dispase treatment, stained for thermal damage by NBTC stain, and lesion diameter was assessed by a blinded investigator. Results The average MTZ diameter exhibits a positive, linear relationship with skin temperature (R2 = 0.904, P < 0.0001). As the skin temperature increases from 0 to 45°C. The MTZ diameter increases from 93 to 147 µm (58%), and the MTZ area from 6,870 to 17,050 µm2 (148%). Conclusion The skin temperature affects the size of epidermal MTZs during fractional photothermolysis and is an important variable factor. The use of simultaneous skin cooling increases patient comfort; however, as it also decreases MTZ size, it may interfere with treatment efficacy. The control of skin temperature is necessary to provide a consistent outcome and to be able to compare treatments. Lasers Surg. Med. 39:14–18, 2007.Keywords
This publication has 18 references indexed in Scilit:
- Results of nonablative wrinkle reduction with a 1,450-nm diode laser: Difficulties in the assessment of “subtle changes”Lasers in Surgery and Medicine, 2005
- Evaluation of different temperatures in cold air cooling with pulsed‐dye laser treatment of facial telangiectasiaLasers in Surgery and Medicine, 2005
- Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal InjuryLasers in Surgery and Medicine, 2004
- Clinical evaluation of enhanced nonablative skin rejuvenation using a combination of a 532 and a 1,064 nm laserLasers in Surgery and Medicine, 2004
- Laser Skin ResurfacingArchives of Dermatology, 1996
- Effects of noxious cooling of the skin on pain perception in manJournal of the Neurological Sciences, 1996
- Laser Resurfacing in Pigmented SkinDermatologic Surgery, 1995
- Skin Resurfacing of Fine to Deep Rhytides Using a Char-free Carbon Dioxide Laser in 47 PatientsDermatologic Surgery, 1995
- Histochemical evaluation of the coagulation depth after argon laser impact on a port‐wine stainLasers in Surgery and Medicine, 1991
- Isolation of a viable eccrine sweat gland by dispaseArchiv für dermatologische Forschung, 1983