Herd immunity to Newcastle disease virus in poultry by vaccination
Open Access
- 16 January 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Avian Pathology
- Vol. 37 (1), 1-5
- https://doi.org/10.1080/03079450701772391
Abstract
International audienceNewcastle disease virus is an economically important disease of poultry for which vaccination is applied as a preventive measure in many countries. Nevertheless, outbreaks have been reported in vaccinated populations. This suggests that either the vaccination coverage level is too low or that vaccination does not provide perfect immunity, allowing the virus to spread in partially vaccinated populations. Here we study the requirements of an epidemiologically effective vaccination program against Newcastle disease in poultry, based on data from experimental transmission studies. The transmission studies indicate that vaccinated birds with low or undetectable antibody titres may be protected against disease and mortality but that infection and transmission may still occur. In fact, our quantitative analyses show that NDV is highly transmissible in poultry with low antibody titres. As a consequence, herd immunity can only be achieved if a high fraction of birds (>85%) has a high antibody titre (log2 haemagglutination inhibition titre≥3) after vaccination. We discuss the implications for the control of Newcastle disease virus in poultry by vaccinationKeywords
This publication has 18 references indexed in Scilit:
- Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implicationsVirus Research, 2006
- Control of Avian Influenza in PoultryEmerging Infectious Diseases, 2006
- Silent spread of H5N1 in vaccinated poultryNature, 2006
- Design and analysis of small-scale transmission experiments with animalsEpidemiology and Infection, 2006
- The challenge of avian influenza to the veterinary communityAvian Pathology, 2006
- Protection of chickens against overt clinical disease and determination of viral shedding following vaccination with commercially available Newcastle disease virus vaccines upon challenge with highly virulent virus from the California 2002 exotic Newcastle disease outbreakVaccine, 2005
- A molecular epidemiological study of avian paramyxovirus type 1 (Newcastle disease virus) isolates by phylogenetic analysis of a partial nucleotide sequence of the fusion protein geneAvian Pathology, 2003
- Experimental quantification of vaccine-induced reduction in virus transmissionVaccine, 1994
- Comparison of the effect of live Newcastle disease vaccine Clone 30 in broilers administered at day 1 or at day 7 and the effect of H120 vaccination at 17 days of age: A field experimentVeterinary Quarterly, 1987
- A unified approach to the distribution of total size and total area under the trajectory of infectives in epidemic modelsAdvances in Applied Probability, 1986