Epithelial-myoepithelial carcinoma of salivary glands.
Open Access
- 1 May 1991
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 44 (5), 419-423
- https://doi.org/10.1136/jcp.44.5.419
Abstract
Four cases of epithelial-myoepithelial carcinoma of the salivary glands arose as painless masses in patients over 60 years old, three in the parotid and one in the submandibular gland. Histologically, all the tumours were composed of small ducts with a double cell lining surrounded by a basement membrane. The inner cells were epithelial and the outer cells myoepithelial, the latter usually possessing clear cytoplasm. There was a variable degree of intervening hyalinised stroma. All the tumours were partly encapsulated, but also displayed local invasiveness. One of the tumours also showed areas of dedifferentiation when it later recurred and metastasised. The other three were apparently cured by initial excision, with adjuvant radiotherapy in one instance. In the past this tumour has been described as clear cell adenoma, and it was only recently that its true malignant nature, albeit low grade, was recognised. Reports of epithelial-myoepithelial carcinoma are still relatively few, with only one case described from Britain. It is recommended that this histologically distinct neoplasm deserves wider recognition.Keywords
This publication has 19 references indexed in Scilit:
- Clear cell carcinoma of minor salivary glandsHistopathology, 1990
- Epithelial‐myoepithelial duct carcinoma of salivary glands: a follow‐up and cytophotometric study of 21 casesJournal of Oral Pathology & Medicine, 1989
- Salivary epithelial-myoepithelial carcinomas of intercalated ducts: A clinical, electron microscopic, and immunocytochemical studyOral Surgery, Oral Medicine, Oral Pathology, 1985
- Myoepithelial cells in salivary gland tumors—revisitedHead & Neck Surgery, 1985
- Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distributionThe Journal of Pathology, 1985
- Epithelial-myoepithelial carcinoma of salivary glandsOral Surgery, Oral Medicine, Oral Pathology, 1984
- Epithelial-myoepithelial carcinoma of intercalated duct origin: A clinicopathologic and ultrastructural assessment of sixteen casesOral Surgery, Oral Medicine, Oral Pathology, 1982
- Salivary gland tumors: review of 643 casesJournal of Oral Pathology & Medicine, 1976
- Diagnosis and ultrastructure of the tubular carcinoma of the salivary gland ductsVirchows Archiv, 1972
- Glycogen‐rich clear‐cell adenoma of the parotid glandThe Journal of Pathology and Bacteriology, 1956