Approaches to the Estimation of Cancer Risk From Ingested PAH
- 1 April 1998
- journal article
- research article
- Published by Informa UK Limited in Polycyclic Aromatic Compounds
- Vol. 12 (4), 249-260
- https://doi.org/10.1080/10406639808233842
Abstract
The sum of eight carcinogenic polycyclic aromatic hydrocarbons (PAH) from food in three total diet studies has ranged from 1.45 to 3.50 μg/person/day. The effect of different approaches to the estimation of possible human cancer risk of food borne sources of PAH was illustrated by combining United Kingdom (UK) intake data with cancer potency information in four different ways. The lifetime cancer risk from this level of exposure, based on the sum of risk from individual PAH was estimated to be 5.1 × 10−5or 8.2 × 10−7for cancer potencies based on rodent studies and human inhalation data respectively. When benzo[a]pyrene was used as a surrogate for the cancer risk of a PAH containing mixture, the risk was estimated at 1.3 × 10−3or 1.1 × 10−5. Variation in dietary intake is small compared with the variation in cancer potency data presently available for risk assessment of PAH from dietary sources.Keywords
This publication has 22 references indexed in Scilit:
- The Contribution of Margarine to Cancer Risk from Polycyclic Aromatic Hydrocarbons in the New Zealand DietPolycyclic Aromatic Compounds, 1996
- Polycyclic aromatic hydrocarbon contamination in the Italian dietFood Additives & Contaminants, 1995
- Assessment of Carcinogenic Risk from Personal Exposure to Benzo(a)pyrene in the Total Human Environmental Exposure Study (THEES)Air & Waste, 1993
- Chemical carcinogens and overnutrition in diet-related cancerCarcinogenesis: Integrative Cancer Research, 1992
- Exposure to carcinogenic PAHs in the environmentEnvironmental Science & Technology, 1992
- Polycyclic aromatic hydrocarbons in Dutch total diet samples (1984–1986)Food and Chemical Toxicology, 1990
- Polycyclic aromatic hydrocarbons (PAH): Carcinogenicity data and risk extrapolationsToxicological & Environmental Chemistry, 1988
- Analysis of polycyclic aromatic hydrocarbons in UK total dietsFood and Chemical Toxicology, 1983
- Polycyclic aromatic hydrocarbons in grilled foodJournal of Agricultural and Food Chemistry, 1983
- The Special Problem of Stomach Cancer in IcelandPublished by American Medical Association (AMA) ,1961