Comparative effects of cefadroxil and phenoxymethylpenicillin on the normal oropharyngeal and intestinal microflora
- 1 May 1997
- journal article
- research article
- Published by Springer Science and Business Media LLC in Infection
- Vol. 25 (3), 154-158
- https://doi.org/10.1007/bf02113603
Abstract
The ecological effects on the commensal microflora in saliva and stool samples were studied during administration of two commonly used antibiotics: cefadroxil 500 mg b.i.d. for 10 days and phenoxymethylpenicillin 1 g b.i.d. for 10 days. Twenty healthy volunteers participated in the study. In the oropharyngeal microflora the aerobic microflora was significantly suppressed during administration of cefadroxil while no significant changes were noticed in the anaerobic microflora. Administration of phenoxymethylpenicillin caused a strong decrease in the number of viridans streptococci and an overgrowth ofNeisseria cocci. The total numbers of anaerobic oropharyngeal microorganisms were suppressed during phenoxymethylpenicillin administration. In the intestinal microflora the variation in numbers of aerobic and anaerobic microorganisms was minor in both groups. The microflora became normalised 2 weeks after withdrawal of the drugs. It was concluded that peroral administration of cefadroxil to healthy volunteers resulted in minor ecological disturbances in the oropharyngeal and intestinal microflora, which were in the same range as for phenoxymethylpenicillin.Keywords
This publication has 9 references indexed in Scilit:
- In vitro activities of 22 beta-lactam antibiotics against penicillin-resistant and penicillin-susceptible viridans group streptococci isolated from bloodAntimicrobial Agents and Chemotherapy, 1995
- The relationship between an increase in β-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbancesJournal of Antimicrobial Chemotherapy, 1994
- Therapy for pharyngitis and tonsillitis caused by group A beta-hemolytic streptococci: a meta-analysis comparing the efficacy and safety of cefadroxil monohydrate versus oral penicillin V.1992
- Studies on the ecological impact of antibioticsEuropean Journal of Clinical Microbiology & Infectious Diseases, 1990
- THE ECOLOGY OF THE HUMAN INTESTINE AND ITS CONSEQUENCES FOR OVERGROWTH BY PATHOGENS SUCH AS CLOSTRIDIUM DIFFICILEAnnual Review of Microbiology, 1989
- Rediscovering Pharmacological Values in Antimicrobial TherapyDrugs, 1986
- Impact of Phenoxymethylpenicillin and Clindamycin on Microflora in Recurrent TonsillitisAnnals of Otology, Rhinology & Laryngology, 1985
- Effect of Phenoxymethylpenicillin and Clindamycin on the Oral, Throat and Faecal Microflora of ManScandinavian Journal of Infectious Diseases, 1979
- Evidence Suggesting Importance of Role of Interbacterial Inhibition in Maintaining Balance of Normal FloraAnnals of Internal Medicine, 1968