PHOTODESTRUCTION OF PHAEOMELANIN
- 30 November 1977
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 26 (6), 651-653
- https://doi.org/10.1111/j.1751-1097.1977.tb07546.x
Abstract
Phaeomelanin readily decomposes by the action of UV light and oxygen. This finding may explain many of the abnormal reactions of the skin of redheads and blondes to sunlight, including their high susceptibility to skin cancer. In aqueous solution, phaeomelanin displays an EPR signal rich in hyperfine splitting, consistent with structural information. SUMMARY Phaeomelanin readily, decomposes by the action of UV light and oxygen. This finding may explain many of the abnormal reactions of the skin of redheads and blondes to sunlight, including their high susceptibility to skin cancer. We have yet to identify any of the fragmentation products. Chromatographic analysis of the photolysate indicates at least 17 different compounds. Work on the reactions of phaeomelanin with superoxide, and the identification, synthesis, and physiological evaluation of these photoproducts as etiological factors in sunburn and carcinogenesis is in progress. In aqueous solutions, phaeomelanin displays an air stable EPR signal rich in hyperfine splitting. Complete analysis of this signal will provide a better understanding of the structure of the pigment.This publication has 16 references indexed in Scilit:
- Melanin pigmentation in mammalsEndeavour, 1976
- The Pigments of Reddish Hair and FeathersAngewandte Chemie-International Edition, 1974
- Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic ProtoporphyriaScience, 1973
- Electron paramagnetic resonance and nuclear spin polarization study of the photooxidation of phenol in waterJournal of the American Chemical Society, 1972
- Singlet oxygen and biological systemsChemico-Biological Interactions, 1971
- The Effects of Ultraviolet Light on Mammalian Pigment Cells in vitro*Journal of Investigative Dermatology, 1969
- Free radicals in human skin before and after exposure to lightArchives of Biochemistry and Biophysics, 1968
- GENETIC SUSCEPTIBILITY AND SOMATIC MUTATION IN THE PRODUCTION OF FRECKLES, BIRTHMARKS, AND MOLESThe Lancet, 1968
- Electron Microscopy of Melanocytes and Melanosomes in Freckled Human EpidermisJournal of Investigative Dermatology, 1964
- Part V: Clinical Applications of Psoralens, and Related Materials: The Epidemiology of Skin Cancer11From The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas.Journal of Investigative Dermatology, 1959