Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
Open Access
- 1 March 2014
- journal article
- Published by Informa UK Limited in International Journal of Nanomedicine
- Vol. 9, 1139-1152
- https://doi.org/10.2147/ijn.s34668
Abstract
Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals Mohammad Farazuddin,1 Bhavyata Dua,2 Qamar Zia,1 Aijaz Ahmad Khan,3 Beenu Joshi,2 Mohammad Owais1 1Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 2Immunology Division, National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL), Agra, 3Department of Anatomy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India Curcumin (diferuloylmethane) is found in large quantities in the roots of Curcuma longa. It possesses strong antioxidant and anti-inflammatory properties, and inhibits chemically-induced carcinogenesis in the skin, forestomach, colon, and liver. Unfortunately, the poor bioavailability and hydrophobicity of curcumin pose a major hurdle to its use as a potent anticancer agent. To circumvent some of these problems, we developed a novel, dual-core microcell formulation of curcumin. The encapsulation of curcumin in microcells increases its solubility and bioavailability, and facilitates slow release kinetics over extended periods. Besides being safe, these formulations do not bear any toxicity constraints, as revealed by in vitro and in vivo studies. Histopathological analysis revealed that curcumin-bearing microcells helped in regression of hepatocellular carcinoma and the maintenance of cellular architecture in liver tissue. Free curcumin had a very mild effect on cancer suppression. Empty (sham) microcells and microparticles failed to inhibit cancer cells. The novel curcumin formulation was found to suppress hepatocellular carcinoma efficiently in Swiss albino mice. Keywords: diferuloylmethane, carcinogenesis, microparticle, nanocells, cancer, Curcuma longaKeywords
This publication has 33 references indexed in Scilit:
- Loading and release of amphotericin-B from biodegradable poly(lactic-co-glycolic acid) nanoparticles.Journal of Biomedical Nanotechnology, 2011
- Curcumin: Getting Back to the RootsAnnals of the New York Academy of Sciences, 2005
- Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcuminCarcinogenesis: Integrative Cancer Research, 2002
- Degradation of phosphatidylcholine in liposomes containing carboplatin in dependence on composition and storage conditionsInternational Journal of Pharmaceutics, 2000
- Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesisCarcinogenesis: Integrative Cancer Research, 2000
- Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-raysCarcinogenesis: Integrative Cancer Research, 1999
- Estimates of the worldwide incidence of 25 major cancers in 1990International Journal of Cancer, 1999
- Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.1999
- Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin.Carcinogenesis: Integrative Cancer Research, 1998
- Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trialsAnnals of Oncology, 1997