Predicting Pneumonia and Influenza Mortality from Morbidity Data
Open Access
- 23 May 2007
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 2 (5), e464
- https://doi.org/10.1371/journal.pone.0000464
Abstract
Few European countries conduct reactive surveillance of influenza mortality, whereas most monitor morbidity. We developed a simple model based on Poisson seasonal regression to predict excess cases of pneumonia and influenza mortality during influenza epidemics, based on influenza morbidity data and the dominant types/subtypes of circulating viruses. Epidemics were classified in three levels of mortality burden (“high”, “moderate” and “low”). The model was fitted on 14 influenza seasons and was validated on six subsequent influenza seasons. Five out of the six seasons in the validation set were correctly classified. The average absolute difference between observed and predicted mortality was 2.8 per 100,000 (18% of the average excess mortality) and Spearman's rank correlation coefficient was 0.89 (P = 0.05). The method described here can be used to estimate the influenza mortality burden in countries where specific pneumonia and influenza mortality surveillance data are not available.Keywords
This publication has 15 references indexed in Scilit:
- Mortality due to Influenza in the United States—An Annualized Regression Approach Using Multiple-Cause Mortality DataAmerican Journal of Epidemiology, 2005
- Semiparametric Estimation of the Duration of Immunity from Infectious Disease Time Series: Influenza as a Case-StudyJournal of the Royal Statistical Society Series C: Applied Statistics, 2005
- Influenza-Associated Hospitalizations in the United StatesJAMA, 2004
- Global Epidemiology of Influenza: Past and PresentAnnual Review of Medicine, 2000
- The impact of influenza epidemics on mortality: introducing a severity index.American Journal of Public Health, 1997
- Influenza mortality among the elderly in France, 1980-90: how many deaths may have been avoided through vaccination?Journal of Epidemiology and Community Health, 1995
- Respiratory syncytial virus or influenza?The Lancet, 1993
- Impact of Influenza on Mortality in Relation to Age and Underlying Disease, 1967–1989International Journal of Epidemiology, 1993
- Influenza: Relation of Mortality to Morbidity Parameters-Netherlands, 1970—1989International Journal of Epidemiology, 1991
- A routine tool for detection and assessment of epidemics of influenza-like syndromes in France.American Journal of Public Health, 1991