Single-atom doping of MoS2 with manganese enables ultrasensitive detection of dopamine: Experimental and computational approach
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Open Access
- 31 July 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 6 (32), eabc4250
- https://doi.org/10.1126/sciadv.abc4250
Abstract
Two-dimensional transition metal dichalcogenides (TMDs) emerged as a promising platform to construct sensitive biosensors. We report an ultrasensitive electrochemical dopamine sensor based on manganese-doped MoS2 synthesized via a scalable two-step approach (with Mn similar to 2.15 atomic %). Selective dopamine detection is achieved with a detection limit of 50 pM in buffer solution, 5 nM in 10% serum, and 50 nM in artificial sweat. Density functional theory calculations and scanning transmission electron microscopy show that two types of Mn defects are dominant: Mn on top of a Mo atom (Mn-t(opMo)) and Mn substituting a Mo atom (Mn-Mo). At low dopamine concentrations, physisorption on Mn-Mo. dominates. At higher concentrations, dopamine chemisorbs on Mn-topMo, which is consistent with calculations of the dopamine binding energy (2.91 eV for Mn-topMo versus 0.65 eV for Mn-Mo). Our results demonstrate that metal-doped layered materials, such as TMDs, constitute an emergent platform to construct ultrasensitive and tunable biosensors.Keywords
Funding Information
- National Science Foundation (432-43 600U)
- National Science Foundation (432-43 600U)
- National Science Foundation (EFRI-1433311)
- National Science Foundation (ACI-1053575)
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