Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
- 24 July 2007
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 104 (30), 12479-12481
- https://doi.org/10.1073/pnas.0705289104
Abstract
Because proinflammatory cytokines are markedly elevated during H5N1 influenza virus infection, the “cytokine storm” is hypothesized to be the main cause of mortality. Here, we demonstrate that mice deficient in the hallmark inflammatory cytokines TNF-α, IL-6, or CC chemokine ligand 2 succumb to infection with A/Vietnam/1203/04 (H5N1) virus, as do wild-type mice treated with glucocorticoids for suppression of cytokines. Because cytokine inhibition does not protect against death, therapies that target the virus rather than cytokines may be preferable.This publication has 41 references indexed in Scilit:
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