Diagnosis of Congenital Adrenal Hyperplasia by Measurement of Plasma 17-Hydroxyprogesterone
Open Access
- 1 February 1972
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 47 (251), 62-65
- https://doi.org/10.1136/adc.47.251.62
Abstract
Measurement of plasma 17-hydroxyprogesterone by a simple competitive protein-binding assay has proved of value in the diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Children with untreated adrenal hyperplasia had high resting levels from as early as the 6th day of life, and children treated with suppressive doses of cortisone showed a rise after adrenal stimulation with tetracosactrin. The method also promises to enhance the ease and precision with which the condition can be managed.Keywords
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