Longitudinal trajectories of BMI and cardiovascular disease risk: The national longitudinal study of adolescent health
Open Access
- 17 October 2013
- Vol. 21 (11), 2180-2188
- https://doi.org/10.1002/oby.20569
Abstract
In adulthood, excess BMI is associated with cardiovascular disease (CVD); it is unknown whether risk differs by BMI trajectories from adolescence to adulthood. The National Longitudinal Study of Adolescent Health, a nationally representative, longitudinal adolescent cohort (mean age: 16.9y) followed into adulthood (mean age: 29.0y) [n=13,643 individuals (40,929 observations)] was examined. Separate logistic regression models for diabetes, hypertension, and inflammation were used to examine odds of risk factors at given adult BMI according to varying BMI trajectories from adolescence to adulthood. CVD risk factor prevalence at follow-up ranged from 5.5% (diabetes) to 26.4% (hypertension) and 31.3% (inflammation); risk differed across BMI trajectories. For example, relative to men aged 27y (BMI=23 kg/m2 maintained over full study period), odds for diabetes were comparatively higher for men of the same age and BMI≈30 kg/m2 with ≈8 BMI unit gain between 15-20y (OR=2.35; 95% CI, 1.51, 3.66) or in those who maintained BMI≈30 kg/m2 across the study period (OR=2.33; 1.92, 2.83) relative to the same ≈8 BMI unit gain, but between 20-27y (OR=1.44; 1.10, 1.87). Specific periods and patterns of weight gain in the transition from adolescence to adulthood might be critical for CVD preventive efforts.Funding Information
- National Institutes of Health (R01HD057194)
- The Carolina Population Center (R24 HD050924)
- University of North Carolina (P01- HD31921)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
This publication has 36 references indexed in Scilit:
- Lifestyle determinants of c-reactive protein in middle-aged, urban Chinese menNutrition, Metabolism and Cardiovascular Diseases, 2012
- Diagnosis and Classification of Diabetes MellitusDiabetes Care, 2011
- Multiple imputation using chained equations: Issues and guidance for practiceStatistics in Medicine, 2010
- Association of Adolescent Obesity With Risk of Severe Obesity in AdulthoodJAMA, 2010
- Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE StudyInternational Journal of Obesity, 2010
- C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomizationInternational Journal of Obesity, 2010
- Standards of Medical Care in Diabetes—2010Diabetes Care, 2010
- Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adultsJournal of Hypertension, 2009
- Mechanisms linking obesity to insulin resistance and type 2 diabetesNature, 2006
- High-Sensitivity Enzyme Immunoassay for C-Reactive Protein in Dried Blood SpotsClinical Chemistry, 2004