Synthesis of Functionalised Bicyclic α-Methylene-γ-butyrolactones from 2, 3-Cyclohexene Acetal via Radical Cyclisation Approach
- 1 April 1991
- journal article
- research article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 21 (7), 885-899
- https://doi.org/10.1080/00397919108019773
Abstract
2, 3-Cyclohexene acetal, wherein the acetal wherein the acetal lunctionality is derived from 2R, 3R(+)-tartaric acid, has been transformed regioselectively into functionalised bicyclic α-methylene-γ-butyrolactoes via radical cyclisations. The radicals were derived from n-bu3SnH reactions with secondary bromides and a tertiary nitro compound.Keywords
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