Advanced Age Is a Risk Factor for Recurrence After Resection in Stage II Colorectal Cancer
Open Access
- 27 December 2019
- journal article
- research article
- Published by Anticancer Research USA Inc. in In Vivo
- Vol. 34 (1), 339-346
- https://doi.org/10.21873/invivo.11779
Abstract
Background/Aim: The number of older patients with colorectal cancer (CRC) is increasing. Stage II CRC is a heterogeneous group of cancers with different prognoses. We aimed to examine older patients in relation to clinical outcome following curative resection in stage II CRC. Patients and Methods: We analyzed data for 329 consecutive patients with stage II CRC following curative resection. Recurrence-free survival (RFS) and overall survival (OS) were compared between older patients ≥75 years of age and those <75 years. Cox proportional hazards model was used to compute hazard ratios (HRs) controlling for potential confounders. Results: In the multivariable analyses, patients ≥75 years were independently associated with shorter RFS (multivariable HR=2.56, 95% confidence interval (CI)=1.55-4.31, p<0.001) and OS (multivariable HR=4.36, 95%CI=2.08-9.97, p<0.001) in stage II CRC. Conclusion: Older patients were independently associated with shorter RFS and OS following curative resection in stage II CRC.Keywords
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