Osteoporosis in β‐Thalassemia: Clinical and Genetic Aspects
- 1 November 2005
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1054 (1), 451-456
- https://doi.org/10.1196/annals.1345.051
Abstract
\ud \ud Osteoporosis and osteopenia are frequent complications of thalassemia major (TM) and intermedia (TI). Osteoporosis was found in 23/25 patients with TI and in 115/239 patients with TM. In TM, no association was found with specific polymorphisms in candidate genes (vitamin D receptor, estrogen receptor, calcitonin receptor, and collagen type 1 alpha 1). Osteoporosis in female patients with TM was strongly associated with primary amenorrhea (P < .0001), while in male patients with TM, hypogonadism was not significantly related to bone mineral density (BMD) (P = .0001). Low BMD was also associated with cardiomiopathy (P = .01), diabetes mellitus (P = .0001), chronic hepatitis (P = .0029), and increased ALT (P = .01).\ud \ud PMID:\ud 16339696\ud [PubMed - indexed for MEDLINEKeywords
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