Lung cancer in octogenarians: factors affecting long-term survival following resection
Open Access
- 1 August 2007
- journal article
- Published by Oxford University Press (OUP) in European Journal of Cardio-Thoracic Surgery
- Vol. 32 (2), 370-374
- https://doi.org/10.1016/j.ejcts.2007.04.002
Abstract
Objective: To identify factors associated with long-term survival following pulmonary resection for lung cancer in patients 80 years of age or older. Methods: The medical records of all patients ≥80 years, who underwent pulmonary resection for lung cancer from 1985 to 2002, were reviewed. Results: There were 294 patients (192 men, 102 women). Median age was 82 years (range 80–94 years). Overall 1-, 2-, and 5-year survival was 80%, 62%, and 34%, respectively. Histologic subtype, diabetes, renal insufficiency, prior myocardial infarction, congestive heart failure or stroke were not significantly associated with differences in 5-year survival. Female gender was associated with increased survival (36.2% vs 32.7% at 5 years, p = 0.04). Extent of preoperative forced expiratory volume in 1 s (FEV1) limitation did not influence survival. However, there were no 5-year survivors amongst patients with dyspnea as their presenting chief complaint, whereas there was a 35% 5-year survival in patients presenting without dyspnea (p ≪ 0.001). Five-year survival by pathologic stage was IA, 48%; IB, 39%; IIA, 17%; IIB, 23%; IIIA, 9%; and IIIB, 0% (p ≪ 0.001). Five-year survival of patients undergoing a lobectomy was 42% versus 11% for pneumonectomy (p ≪ 0.001). Conclusions: Meaningful long-term survival is obtainable in elderly patients undergoing surgical resection for lung cancer. Careful patient evaluation and selection is necessary to identify patients who will benefit most from resection. Shorter survival was observed in male patients and those presenting with dyspnea. As could be expected, survival was also dependent on extent of resection and initial pathologic stage.This publication has 16 references indexed in Scilit:
- Lung Cancer in Octogenarians: Factors Affecting Morbidity and Mortality After Pulmonary ResectionThe Annals of Thoracic Surgery, 2006
- Surgical Resection for Lung Cancer in the OctogenarianSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2004
- Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experienceThe Annals of Thoracic Surgery, 2004
- Surgical strategy for clinical stage I non-small cell lung cancer in octogenariansEuropean Journal of Cardio-Thoracic Surgery, 2003
- Pulmonary complications after surgical treatment of lung cancer in octogenariansEuropean Journal of Cardio-Thoracic Surgery, 2000
- Results of surgical treatment of lung cancer in octogenariansLung Cancer, 1999
- Revisions in the International System for Staging Lung CancerSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1997
- Pulmonary Resection for Lung Cancer in OctogenariansThe Annals of Thoracic Surgery, 1997
- Surgical treatment of lung cancer in the octogenarianThe Annals of Thoracic Surgery, 1994
- Results of resection for bronchogenic carcinoma in patients over the age of 80.Thorax, 1989