Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH
- 14 January 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 46 (8), 1299-1301
- https://doi.org/10.1039/b922050j
Abstract
We now present the first example in which triplet repeat DNAs adopt the i-motif structure at neutral pH by molecular crowding. Crowding stabilized the i-motif and the pKa of N3 of cytosine was raised in such a microenvironment. Molecular crowding is known to accelerate the formation of the multi-stranded i-motif while the triplet repeats adopt the single-strand structure.Keywords
This publication has 23 references indexed in Scilit:
- Non-B DNA structure-induced genetic instabilityMutation Research - Reviews in Mutation Research, 2006
- Join the crowdNature, 2003
- Intramolecular Higher Order Packing of Parallel Quadruplexes Comprising a G:G:G:G Tetrad and a G(:A):G(:A):G(:A):G Heptad of GGA Triplet Repeat DNAPublished by Elsevier BV ,2003
- The Influence of Macromolecular Crowding and Macromolecular Confinement on Biochemical Reactions in Physiological MediaPublished by Elsevier BV ,2001
- Structure and Dynamics of the DNA Hairpins Formed by Tandemly Repeated CTG Triplets Associated With Myotonic DystrophyNucleic Acids Research, 1996
- Macromolecular Crowding: Biochemical, Biophysical, and Physiological ConsequencesAnnual Review of Biophysics and Biophysical Chemistry, 1993
- DNA structure, mutations, and human genetic diseaseCurrent Opinion in Biotechnology, 1992
- Survey of human and rat microsatellitesGenomics, 1992
- Intramolecular DNA triplexes in supercoiled plasmids.Proceedings of the National Academy of Sciences of the United States of America, 1988
- Hierarchical order in chromosome-specific human alpha satellite DNATrends in Genetics, 1987