Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
Open Access
- 18 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virology Journal
- Vol. 9 (1), 23
- https://doi.org/10.1186/1743-422x-9-23
Abstract
Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4α and HNF3β with the severity of HBV-infected liver diseases is unclear. In this study, liver tissue samples from different types of HBV patients were collected, and HNF4α and HNF3β expression were detected by immunohistochemistry. The expression of HNF4α was significant higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) (both P < 0.05), but similar between patients with CHB and LC (P > 0.05). And the expression of HNF3β was similar among patients with CHB, LC and SHB (P > 0.05 for all pairwise comparison). This suggests that the expression level of HNF4α was different in patients with different outcome of HBV infection, high expression level of HNF4α may correlate with occurrence of SHBKeywords
This publication has 21 references indexed in Scilit:
- Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4αBMC Genomics, 2011
- The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patientsJournal of Viral Hepatitis, 2009
- Natural History of Hepatitis B Virus Infection: An Update for CliniciansMayo Clinic Proceedings, 2007
- Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phaseHepatology, 2007
- Transcription factors in liver development, differentiation, and regenerationHepatology, 2003
- Induction of Prothrombinase fgl2 by the Nucleocapsid Protein of Virulent Mouse Hepatitis Virus Is Dependent on Host Hepatic Nuclear Factor-4αJournal of Biological Chemistry, 2003
- Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In VivoJournal of Virology, 2002
- Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathwayBiochemical Journal, 2002
- Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3βJournal of Virology, 2002
- Replication of the Wild Type and a Natural Hepatitis B Virus Nucleocapsid Promoter Variant Is Differentially Regulated by Nuclear Hormone Receptors in Cell CultureJournal of Virology, 2001