The Oxidative Mannich Reaction Catalyzed by Dirhodium Caprolactamate
- 8 April 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (17), 5648-5649
- https://doi.org/10.1021/ja061146m
Abstract
Dirhodium caprolactamate [Rh2(cap)4] is a highly effective catalyst for the oxidative Mannich reaction. The reaction proceeds via C−H oxidation of a tertiary amine followed by nucleophilic capture. This green transformation is conducted in protic solvent using inexpensive T-HYDRO (70% t-BuOOH in water). Synthetically valuable γ-aminoalkyl butenolides are obtained.Keywords
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