Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice
Open Access
- 1 May 2002
- journal article
- Published by Elsevier BV
- Vol. 277 (22), 19353-19357
- https://doi.org/10.1074/jbc.m201584200
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxesJournal of Molecular Biology, 2000
- Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.JCI Insight, 1998
- Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.JCI Insight, 1998
- Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.JCI Insight, 1997
- Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.JCI Insight, 1997
- Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.JCI Insight, 1996
- ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.Genes & Development, 1996
- Positional cloning of the mouse obese gene and its human homologueNature, 1994
- Diet-Induced Hypercholesterolemia in Mice: Prevention by Overexpression of LDL ReceptorsScience, 1990
- Hereditary Diabetes in Genetically Obese MiceScience, 1951