Sequence of retrovirus provirus resembles that of bacterial transposable elements
- 1 June 1980
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 285 (5766), 550-554
- https://doi.org/10.1038/285550a0
Abstract
The nucleotide sequences of the terminal regions of an infectious integrated retrovirus cloned in the modified λ phage cloning vector Charon 4A have been elucidated. There is a 569-base pair direct repeat at both ends of the viral DNA. The cell–virus junctions at each end consist of a 5-base pair direct repeat of cell DNA next to a 3-base pair inverted repeat of viral DNA. This structure resembles that of a transposable element and is consistent with the protovirus hypothesis that retroviruses evolved from the cell genome.Keywords
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