Conservation and evolution of gene coexpression networks in human and chimpanzee brains
- 21 November 2006
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 103 (47), 17973-17978
- https://doi.org/10.1073/pnas.0605938103
Abstract
Comparisons of gene expression between human and non-human primate brains have identified hundreds of differentially expressed genes, yet translating these lists into key functional distinctions between species has proved difficult. Here we provide a more integrated view of human brain evolution by examining the large-scale organization of gene coexpression networks in human and chimpanzee brains. We identify modules of coexpressed genes that correspond to discrete brain regions and quantify their conservation between the species. Module conservation in cerebral cortex is significantly weaker than module conservation in subcortical brain regions, revealing a striking gradient that parallels known evolutionary hierarchies. We introduce a method for identifying species-specific network connections and demonstrate how differential network connectivity can be used to identify key drivers of evolutionary change. By integrating our results with comparative genomic sequence data and estimates of protein sequence divergence rates, we confirm a number of network predictions and validate these findings. Our results provide insights into the molecular bases of primate brain organization and demonstrate the general utility of weighted gene coexpression network analysis.This publication has 30 references indexed in Scilit:
- Evolution of primate gene expressionNature Reviews Genetics, 2006
- Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and ChimpanzeesScience, 2005
- A genome-wide comparison of recent chimpanzee and human segmental duplicationsNature, 2005
- A General Framework for Weighted Gene Co-Expression Network AnalysisStatistical Applications in Genetics and Molecular Biology, 2005
- Regional Patterns of Gene Expression in Human and Chimpanzee BrainsGenome Research, 2004
- Conservation and Coevolution in the Scale-Free Human Gene Coexpression NetworkMolecular Biology and Evolution, 2004
- A Neutral Model of Transcriptome EvolutionPLoS Biology, 2004
- Network biology: understanding the cell's functional organizationNature Reviews Genetics, 2004
- Genomic Divergences between Humans and Other Hominoids and the Effective Population Size of the Common Ancestor of Humans and ChimpanzeesAmerican Journal of Human Genetics, 2001
- The Symbolic Species: The Co-Evolution of Language and the BrainThe Modern Language Journal, 1998