A look at autoimmunity and inflammation in the eye
Top Cited Papers
Open Access
- 1 September 2010
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 120 (9), 3073-3083
- https://doi.org/10.1172/jci42440
Abstract
Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.Keywords
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