MicroRNAs in Adult and Embryonic Neurogenesis
- 14 July 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in NeuroMolecular Medicine
- Vol. 11 (3), 141-152
- https://doi.org/10.1007/s12017-009-8077-y
Abstract
Neurogenesis is defined as a process that includes the proliferation of neural stem/progenitor cells (NPCs) and the differentiation of these cells into new neurons that integrate into the existing neuronal circuitry. MicroRNAs (miRNAs) are a recently discovered class of small non-protein coding RNA molecules implicated in a wide range of diverse gene regulatory mechanisms. More and more data demonstrate that numerous miRNAs are expressed in a spatially and temporally controlled manners in the nervous system, which suggests that miRNAs have important roles in the gene regulatory networks involved in both brain development and adult neural plasticity. This review summarizes the roles of miRNAs-mediated gene regulation in the nervous system with focus on neurogenesis in both embryonic and adult brains.Keywords
This publication has 103 references indexed in Scilit:
- Origins and Mechanisms of miRNAs and siRNAsCell, 2009
- Applications of next-generation sequencing technologies in functional genomicsGenomics, 2008
- MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiationExperimental Cell Research, 2008
- The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and AngiogenesisDevelopmental Cell, 2008
- Identification of microRNAs and other small regulatory RNAs using cDNA library sequencingMethods, 2008
- Members of the miRNA-200 Family Regulate Olfactory NeurogenesisNeuron, 2008
- Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cellsDevelopmental Biology, 2007
- Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult BrainCell, 2007
- The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA SplicingMolecular Cell, 2007
- A Mammalian microRNA Expression Atlas Based on Small RNA Library SequencingCell, 2007