Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
- 1 February 1989
- journal article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 45 (2), 209-211
- https://doi.org/10.1007/bf01954881
Abstract
The African tree Combretum caffrum (Combretacae) has been found to contain a powerful inhibitor of tubulin polymerization (IC50 2-3 microM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50 approximately 0.003 microM and human colon cancer cell lines [(e.g. LoVo (ED50 = 0.005 microgram/ml), HT 29 (ED50 0.02 microgram/ml, Colo 205 (ED50 = 0.07 microgram/ml), DLD-1 (ED50 = 0.005 microgram/ml) and HCT-15 (ED50 = 0.0009 microgram/ml] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.Keywords
This publication has 3 references indexed in Scilit:
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- Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrumJournal of Natural Products, 1987
- Isolation and structure of combretastatinCanadian Journal of Chemistry, 1982