Specificity of Intramembrane Protein-Lipid Interactions
Open Access
- 2 May 2011
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 3 (6), a004705
- https://doi.org/10.1101/cshperspect.a004705
Abstract
Our concept of biological membranes has markedly changed, from the fluid mosaic model to the current model that lipids and proteins have the ability to separate into microdomains, differing in their protein and lipid compositions. Since the breakthrough in crystallizing membrane proteins, the most powerful method to define lipid-binding sites on proteins has been X-ray and electron crystallography. More recently, chemical biology approaches have been developed to analyze protein–lipid interactions. Such methods have the advantage of providing highly specific cellular probes. With the advent of novel tools to study functions of individual lipid species in membranes together with structural analysis and simulations at the atomistic resolution, a growing number of specific protein–lipid complexes are defined and their functions explored. In the present article, we discuss the various modes of intramembrane protein–lipid interactions in cellular membranes, including examples for both annular and nonannular bound lipids. Furthermore, we will discuss possible functional roles of such specific protein–lipid interactions as well as roles of lipids as chaperones in protein folding and transport.Keywords
This publication has 100 references indexed in Scilit:
- Binding of Anionic Lipids to at Least Three Nonannular Sites on the Potassium Channel KcsA is Required for Channel OpeningBiophysical Journal, 2008
- Membrane lipids: where they are and how they behaveNature Reviews Molecular Cell Biology, 2008
- Mutation of a single residue, β‐glutamate‐20, alters protein–lipid interactions of light harvesting complex IIMolecular Microbiology, 2007
- Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidaseThe EMBO Journal, 2007
- The multiple faces of caveolaeNature Reviews Molecular Cell Biology, 2007
- Molecular Dynamics Simulations of SOPS and Sphingomyelin Bilayers Containing CholesterolBiophysical Journal, 2007
- GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranesBiochemical and Biophysical Research Communications, 2005
- Crystal structure of spinach major light-harvesting complex at 2.72 Å resolutionNature, 2004
- Lipids in the Structure, Folding, and Function of the KcsA K+ ChannelBiochemistry, 2002
- Control of topology and mode of assembly of a polytopic membrane protein by positively charged residuesNature, 1989