The Production of Mullerian Inhibiting Substance by the Fetal, Neonatal and Adult Rat1

Abstract

The secretory pattern of Mullerian Inhibiting Substance in the rat was documented by a graded organ culture assay on each day of the perinatal period and at more widely spaced intervals in the adult period. The influence of placenta and pituitary on Mullerian Inhibiting Substance production was studied. Fetal testicular fragments were displaced from target Mullerian ducts to determine if Mullerian Inhibiting Substance would act at a distance.