Insights into Acinetobacter War-Wound Infections, Biofilms, and Control
- 1 April 2010
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Advances in Skin & Wound Care
- Vol. 23 (4), 169-174
- https://doi.org/10.1097/01.asw.0000363527.08501.a3
Abstract
Multidrug-resistant Acinetobacter baumannii is associated with a wide spectrum of infectious diseases ranging from nosocomial, community-acquired infections to those acquired following war or natural disaster. Especially to military personnel with war wounds, Acinetobacter infection is a formidable threat. The treatment has become exceedingly difficult, not only because the bacterium can develop extensive antimicrobial resistance but because it also forms biofilms that are resistant to host defense and antimicrobial treatment. Such causative factors as biofilm formation and resistance are highly likely to lead to nonhealing wounds. This review, although focused on A baumannii infections, aims to summarize what is known about immunization protection against wound biofilm infections and to apply such understanding in exploring the unknown area of war-wound infection protection. Publications were searched and selected through http://www.pubmed.gov by using the key words Acinetobacter baumannii, bacteria, war wounds, burn wounds, wound infections, biofilms, vaccines, and immunization. The literature selected was categorized according to the subheadings within this article. It is imperative to develop such effective measures as active and passive immunization to control multidrug-resistant and tenacious A baumannii infections and to prevent nonhealing wounds. The authors' understanding in immunization against burn wound-related infections by the model bacteria will facilitate research progress in the poorly explored area of immunization against war-wound biofilm infections.Keywords
This publication has 58 references indexed in Scilit:
- Rat Pneumonia and Soft-Tissue Infection Models for the Study of Acinetobacter baumannii BiologyInfection and Immunity, 2008
- Identification and Characterization of an Acinetobacter baumannii Biofilm-Associated ProteinJournal of Bacteriology, 2008
- Why chronic wounds will not heal: a novel hypothesisWound Repair and Regeneration, 2007
- Multi-drug resistant A cinetobacterinfections in critically injured Canadian forces soldiersBMC Infectious Diseases, 2007
- Pseudomonas aeruginosa Forms Biofilms in Acute Infection Independent of Cell-to-Cell SignalingInfection and Immunity, 2007
- Susceptibility of Acinetobacter Strains Isolated from Deployed U.S. Military PersonnelAntimicrobial Agents and Chemotherapy, 2007
- Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical CenterAntimicrobial Agents and Chemotherapy, 2006
- Aminoglycoside antibiotics induce bacterial biofilm formationNature, 2005
- Bacterial resistance to antibiotics: Modified target sitesAdvanced Drug Delivery Reviews, 2005
- Bacterial biofilms: from the Natural environment to infectious diseasesNature Reviews Microbiology, 2004