Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease
- 27 November 2008
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 359 (22), 2355-2365
- https://doi.org/10.1056/nejmra0800353
Abstract
New molecular, cellular, and immunologic techniques used to study host–pathogen interactions have led to a reexamination of the role of infection in chronic obstructive pulmonary disease (COPD). There is now considerable evidence that infection plays a major role in the pathogenesis and clinical course of COPD. A vicious circle of infection and inflammation is thought to lead to exacerbations of the disease.Keywords
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