An aminomethylpyrimidine DPP-IV inhibitor with improved properties
- 1 July 2004
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (13), 3575-3578
- https://doi.org/10.1016/j.bmcl.2004.04.048
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituentsBioorganic & Medicinal Chemistry Letters, 2004
- Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treatment of Type 2 diabetesExpert Opinion on Therapeutic Patents, 2003
- Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetesExpert Opinion on Investigational Drugs, 2003
- Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4.Drug Metabolism and Disposition, 2002
- Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 InhibitionClinical Pharmacokinetics, 2000
- Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption ProcessesJournal of Medicinal Chemistry, 1998
- A Novel Solution‐ and Solid‐Phase Approach to 2,4,5‐tri‐ and 2,4,5,6‐tetrasubstituted pyrimidines and their conversion into condensed heterocyclesHelvetica Chimica Acta, 1998
- The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivoToxicology, 1996
- Atom/Fragment Contribution Method for Estimating Octanol–Water Partition CoefficientsJournal of Pharmaceutical Sciences, 1995
- Drug-induced lysosomal storage of sulfated glycosaminoglycans. Studies on the underlying structure-activity relationshipsToxicology, 1993